Research was conducted at the Fortuna Research and Development Center to study the growth and yield of mango trees at three development stages of different rootstock and scion combinations. Scion diameter varied with age but after 6 years, Palmer was thickest followed by Edward and Irwin. Eldon was the most effective rootstock in reducing scion diameter during the first 6 years; its effect disappeared after the trees were 9 years old. Scion to rootstock ratio varied with age. After 9 years of growth the combination of Edward on Manzano Tetenené showed the lowest ratio. After 6 years of growth Edward had the largest canopy, but after 9 years it was surpassed by Palmer, followed by Edward and Irwin. Eldon, as rootstock for Palmer and Irwin, produced the smallest canopy irrespective of tree age. Regardless of rootstock, the order in height was Palmer, Edward, Irwin. Eldon as rootstock produced significantly smaller Irwin and Palmer trees, although after 9 years the effect of rootstock on tree height was not significant. In varieties Edward and Palmer yield efficiency decreased with age and height, but was not significantly affected by the rootstock. However, yield decreased significantly when Irwin was grafted on Julie. Fruit production per tree and total weight of fruits were related to a reduction in size, with a significant reduction in total number and weight of fruits produced.